Improving Intact Antibody and Plasma Glycoprotein Analysis with Native MS and Parsimonious Charge Deconvolution

Improving Intact Antibody and Plasma Glycoprotein Analysis with Native MS and Parsimonious Charge Deconvolution

Recent developments in mass spectrometry technology have enabled the analysis of intact native glycoproteins and protein complexes using Orbitrap mass analyzers with extended mass ranges.

High sensitivity and resolution enable the profiling of critical quality attributes and biosimilarity of protein biotherapeutics in their native states with minimal sample preparation.

In this webinar, Albert Heck, Ph.D., will describe native mass spectrometry and the Orbitrap EMR. Dr. Heck will also describe how high-resolution native mass spectrometry along with a new “parsimonious” charge deconvolution algorithm enables his laboratory to analyze targets that were previously too difficult for intact mass analysis.

Attend this webinar to discover

How to deconvolve wide m/z and m ranges, with high dynamic range, while producing minimal artifacts
Native mass spectrometry using Orbitrap platforms
The impact of Intact Mass™ to improve speed, sensitivity and avoidance of algorithmic artifacts
Difficult targets including ADCs, complex proteoforms and large protein assemblies
How to automatically match proteoform masses, including clips
Hybrid bottom-up / intact analysis of highly glycosylated proteins

Overview

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Webinar Summary

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