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Webinar Summary

Therapeutic development for human diseases continues to face obstacles, particularly in translating targets or compounds identified by in vitro screening campaigns to valid targets or efficacious and safe compounds once tested in humans.

Here we discuss strategies that leverage induced pluripotent stem cells (iPSCs) to increase the relevance of human cell models for these in vitro approaches. We review current advances in genome engineering to pivot from challenges with delivery, identification and selection and subsequent clonal outgrowth by leveraging tools to consistently and reliably generate knock-out and knock-in models for use in target or compound identification.

Attend this Webinar to:
  • Elucidate effective strategies for building disease models predictive of in vitro and in vivo results leveraging induced pluripotent stem cells (iPSCs)
  • Review current advances in genome engineering to alleviate challenges with delivery, identification and selection and subsequent clonal outgrowth
  • Walk away with a reproducible workflow for successful development of disease models utilizing genome editing and stem cells

Speaker Information:

Erik Willems
Erik Willems
Staff Scientist
Thermo Fisher Scientific