Addressing Key Biotherapeutic Challenges With Novel Chromatography Resins

Biotherapeutic Challenges
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Biotherapeutic Challenges

Advances in monoclonal antibodies and biotherapeutics are generating a wider range of biomolecules. However, with this molecular diversity, unique separation and purification challenges arise that are often difficult to overcome. Typical impurities include nucleic acids (DNA, RNA), host cell proteins, aggregates and glycosylation and charge variants, as well as potential viral contamination. These impurities can prove problematic to separate but need to be cleared to acceptable levels in accordance with guidelines established by regulatory agencies.

Download this whitepaper to discover hydrophobic interaction chromatography resins that:

  • Provide unique selectivity towards target molecules
  • Have excellent resolution, even at lower conductivity conditions
  • Deliver flow rate independent performance leading to a reduction in processing times