--- title: Advancing Top-Down Proteomics for Precision Medicine on the timsTOF Pro description: The structure, activity, and function of proteins are modulated by posttranslational modifications (PTMs) which yield diverse molecular forms of individual expressed proteins. image: https://go.technologynetworks.com/hubfs/Bruker_timsTOF%20Pro_Sep23_640x360_SocialBanner.png --- WEBINAR # Advancing Top-Down Proteomics for Precision Medicine on the timsTOF Pro Watch On-Demand ![WebinarsBY-TN-White](https://go.technologynetworks.com/hubfs/WebinarsBY-TN-White.png "WebinarsBY-TN-White")     The structure, activity, and function of proteins are modulated by posttranslational modifications (PTMs) which yield diverse molecular forms of individual expressed proteins. [Read More Below](https://go.technologynetworks.com/advancing-top-down-proteomics#webinar-summary) Brought to you by ![bruker_logo](https://go.technologynetworks.com/hs-fs/hubfs/Technology%20Networks/TN%20Webinars/2020/29th%20April%202020%20-%20Bruker/bruker_logo.png?width=186&height=98&name=bruker_logo.png "bruker_logo") **Watch On-Demand Today!** ### Webinar Summary To understand biological systems at a functional level, a comprehensive picture of the diverse forms proteins can take is crucial. Top-down mass spectrometry (MS)-based proteomics provides a comprehensive analysis of such proteoforms, but the extraordinary dynamic range of the human proteome has meant that the MS detection of low-abundance proteins has remained an unsolved challenge. New strategies in top-down proteomics for precision medicine enabled by the timsTOF Pro are however helping to change this. In this webinar, David Roberts will present novel top-down proteomics and nanotechnology approaches for the sensitive enrichment, analysis, and characterization of low-abundance protein biomarkers. Moreover, David will reveal a first-hand look at how the timsTOF Pro enables in-depth proteomics for the high-throughput proteomic analysis of 3D human induced pluripotent stem cell-derived engineered cardiac tissues assisted by a novel photo-cleavable surfactant, Azo. Lastly, David will demonstrate new native ion mobility MS approaches for the in-depth characterization of native antibody drug conjugates with high sensitivity. **In this webinar you will learn about: ** - Top-down proteomics approaches for in-depth biomarker analysis toward precision medicine - How rationally designed nanomaterials can enable the sensitive and specific enrichment of low-abundance proteins - How TIMS enhances intact protein analysis and characterization and enables high-throughput, in-depth proteome coverage - timsTOF Pro-enabled native MS characterization of antibody drug conjugates **Speaker Information:** ![WebinarSpeakerImage](https://go.technologynetworks.com/hs-fs/hubfs/Technology%20Networks/TN%20Webinars/2020/23rd%20September%202020%20-%20Bruker/WebinarSpeakerImage.png?width=140&name=WebinarSpeakerImage.png) **David S. Roberts** Chemistry PhD Student Ying Ge Lab and Song Jin Lab, University of Wisconsin-Madison [![Share on Facebook](https://go.technologynetworks.com/hs-fs/hubfs/Images/TN/Landing%20Page%20Template%20Images/Other/FB.png?width=24&name=FB.png)](http://www.facebook.com/share.php?u=https%3A%2F%2Fgo.technologynetworks.com%2Fadvancing-top-down-proteomics%3Futm_medium%3Dsocial%26utm_source%3Dfacebook) [![Share on LinkedIn](https://go.technologynetworks.com/hs-fs/hubfs/Images/TN/Landing%20Page%20Template%20Images/Other/linkedIn.png?width=24&name=linkedIn.png)](http://www.linkedin.com/shareArticle?mini=true&url=https%3A%2F%2Fgo.technologynetworks.com%2Fadvancing-top-down-proteomics%3Futm_medium%3Dsocial%26utm_source%3Dlinkedin) [![Share on Twitter](https://go.technologynetworks.com/hs-fs/hubfs/Images/TN/Landing%20Page%20Template%20Images/Other/Twitter.png?width=24&name=Twitter.png)](https://twitter.com/intent/tweet?original_referer=https%3A%2F%2Fgo.technologynetworks.com%2Fadvancing-top-down-proteomics%3Futm_medium%3Dsocial%26utm_source%3Dtwitter&url=https%3A%2F%2Fgo.technologynetworks.com%2Fadvancing-top-down-proteomics%3Futm_medium%3Dsocial%26utm_source%3Dtwitter&source=tweetbutton&text=Advancing%20Top-Down%20Proteomics%20for%20Precision%20Medicine%20on%20the%20timsTOF%20Pro) [![Share on Email](https://go.technologynetworks.com/hs-fs/hubfs/Images/TN/Landing%20Page%20Template%20Images/Other/email.png?width=24&name=email.png)](mailto:?subject=Check%20out%20https%3A%2F%2Fgo.technologynetworks.com%2Fadvancing-top-down-proteomics%3Futm_medium%3Dsocial%26utm_source%3Demail%20&body=Check%20out%20https%3A%2F%2Fgo.technologynetworks.com%2Fadvancing-top-down-proteomics%3Futm_medium%3Dsocial%26utm_source%3Demail) ![WhiteTwoLine](https://go.technologynetworks.com/hubfs/WhiteTwoLine.png "WhiteTwoLine")   Technology Networks Limited Woodview | Bull Lane Industrial Estate | Sudbury | C010 0FD | UK [Email: privacy@technologynetworks.com](mailto:privacy@technologynetworks.com?Subject=Privacy) © 2020 Technology Networks, All rights reserved Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. 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