The number of applications for supercritical fluid chromatography (SFC) is constantly growing. This is mainly due to the unique separation characteristics of SFC, which facilitate separation of a broad range of compounds with high efficiency.
Almost all achiral stationary phases known in liquid chromatography (LC) can be used in SFC, offering a broad selectivity. However, due to the compressibility of the mobile phase and the retention mechanism in SFC, method development can be a challenging task.
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