Automated Method Development for Pharmaceuticals



The number of applications for supercritical fluid chromatography (SFC) is constantly growing. This is mainly due to the unique separation characteristics of SFC, which facilitate separation of a broad range of compounds with high efficiency.

Almost all achiral stationary phases known in liquid chromatography (LC) can be used in SFC, offering a broad selectivity. However, due to the compressibility of the mobile phase and the retention mechanism in SFC, method development can be a challenging task.

Download this application note to find out more about:

  • Read how six different pharmaceutical active compounds were separated and detected by SFC/time-of-flight mass spectrometry.
  • Discover the benefits of software-assisted method development in achiral SFC.
  • Learn how ChemStation Method Scouting Wizard software significantly reduces the time necessary to create screening procedures.