It is now known that gene function can be modified by more than just changes in an individual’s DNA sequence. Heritable changes in gene expression, caused by the activation and silencing of genes, can be achieved by epigenetic markers – chemical “tags” that feature on proteins that associate with DNA, as well as the DNA strand itself. Today, there is growing evidence that in various diseases, including different types of cancer, there are underlying epigenetic mechanisms at play.
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- Hyper and hypomethylation in cancer
- Histone modifications, chromatin remodeling and non-coding RNA
Epigenetic therapies for cancer