Cancer cells engage in a complex array of interactions with neighboring cancerous and stromal cells. They interact via direct cell-to-cell contact, paracrine signaling, long-range interactions with distal organ sites involving circulating extracellular vesicles as well as signaling via cytokines, hormones and growth factors.These signaling events play a crucial role in the survival of cancer cells, metastatic spread and immune evasion. They also help our understanding of how cancer cells communicate with each other, their immediate microenvironment and with distal organ sites. This information is crucial for developing effective therapeutic strategies to prevent cancer initiation, progression and metastasis.
Recent advances in single-cell sequencing, 3D organoid cultures and intravital imaging provide great insight into cancer cell communication at a single-cell level. The advances have provided insight into patient-level differences in responses as well as noting the tremendous role of heterogeneity at the level of tumor composition, microenvironment and vasculature.
In this webinar, Dr. Holz will discuss the background of cell-to-cell communication, highlighting studies and recent developments in the field as well as exploring the clinical implications of these studies on cancer biology and patient care.
Attend this webinar to:
- Learn the complexities of cell-to-cell communication in the context of cancer
- Discover incredible studies and recent developments in this field
- Explore the clinical implications of these studies on cancer biology and patient care