Comprehending COVID-19: Peptide Mapping of the SARS-CoV-2 Spike Protein

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The SARS-CoV-2 spike protein has rightly garnered attention as a leading candidate for protein-based vaccines for COVID-19. Multiple studies have shown that neutralizing antibodies bind to the spike protein at both peptide and peptidoglycan epitopes. Peptide mapping analyses by liquid chromatography and mass spectrometry might therefore prove to be very useful during the development and QC analysis of new protein-based vaccine candidates for the novel coronavirus.

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