Charge variants separation of monoclonal antibodies can be a challenging task for chromatographers. Due to the microheterogeneity of monoclonal antibodies, extensive method development can be necessary to find the optimal desired resolution. Outperforming many traditional salt gradients, the resolving power of pH gradients enables the separation of charge variants in a very efficient way.
Download this app note to discover a liquid chromatography system for charge variant analysis that:
- Delivers highly reliable and reproducible results
- Simplifies the bioanalysis workflow
- Reduces the time required for buffer preparation
