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Fundamentals of Therapeutic Drug Monitoring: Definition, Importance and Methods

Therapeutic drug monitoring (TDM) is the measurement of circulating concentrations of a drug to adjust its dosing regimen, so as to reach a defined target exposure associated with optimal efficacy and minimal toxicity. Samples are collected at a known time relative to the administration of the last dose. Early development of TDM is largely attributed to University of California researchers Lewis Sheiner and Stuart Beal, who created NONMEM, a software for pharmacokinetics modeling.

Download this listicle to discover answers to key questions such as:

  • Can therapeutic drug monitoring be used for all drugs?
  • Which drugs are currently monitored using TDM approaches?
  • What analytical methods are used for therapeutic drug monitoring?


Download this listicle to discover answers to
key questions such as:

  • Can therapeutic drug monitoring be used for all drugs?
  • Which drugs are currently monitored using TDM approaches?
  • What analytical methods are used for therapeutic drug monitoring?

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