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Lipid nanoparticles (LNP) play a key role in effectively protecting and transporting mRNA to target cells in mRNA-based vaccines and therapeutics. To ensure the quality and safety of LNP, lipid components and associated impurities/degradants need to be carefully characterized in raw materials and formulation. The lipids and their metabolites need to be identified and quantified to understand their distribution, clearance and biodegradation pathways in the body.
- Confident LNP component confirmation using HRAM MS and MS/MS data
- Confident identification of low abundant lipid impurities and degradants at <0.1% in LNP formulations
- Simultaneous lipid quantification and unknown metabolite identification with LOD of 0.1ng/mL in complex biological matrices
