Most small molecule drugs and biologics, including monoclonal antibodies, interact with a therapeutic target to alter its function. Traditional analytical techniques such as fluorescence-based assays involve tagging analytes or secondary reagents with a fluorescent moiety. Labeling is typically not site-specific and can lead to structural alterations that may affect its activity. Data quality issues can also arise due to interference from fluorescent labels.
Modern analytical techniques designed for real-time analysis and high-throughput capabilities significantly reduce the time taken to discover promising therapeutics with the best chances for success downstream.
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