How Cells Know They’re Infected with SARS-CoV-2 and How The Subsequent Response To This Results in COVID-19

Almost every cell of the 30 trillion that comprise the human body has the capacity to recognize when they are infected with a virus.

Once aware of this threat, the infected cell has two main responsibilities. First, the cell must launch a call to arms.

This task requires the secretion of a signal (interferon) that informs the surrounding cells of the imminent threat and instructing them to fortify their defences.

The second responsibility is to launch a call for reinforcements. This task also requires a secreted signal (chemokines) that recruits more sophisticated immune cells to the site of infection.

Attendees will learn how

• Host cells detect the presence of SARS-CoV-2
• The host immune response dynamics play out in response to      SARS-CoV-2
• SARS-CoV-2 blocks only aspects of the host cellular response
• Interactions between the virus and host ultimately result in COVID-19

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