---
title: Identification of Structural Variation in Chimpanzees Using Optical Mapping and Nanopore Sequencing
description: Structural variation, including deletions and inversions, accounts for a large proportion of the genetic differences observed between and within great ape species, making them an important source of trait divergence.
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---

WEBINAR

# Identification of Structural Variation in Chimpanzees Using Optical Mapping and Nanopore Sequencing

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Structural variation, including deletions and inversions, accounts for a large proportion of the genetic differences observed between and within great ape species, making them an important source of trait divergence.

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### Webinar Summary

Structural variation, including deletions and inversions, accounts for a large proportion of the genetic differences observed between and within great ape species, making them an important source of trait divergence.

We used nanopore sequencing and optical mapping to characterize the structural variant landscape of two *Pan troglodytes verus* individuals.

Filtering for variants >10 kbp, we identified 425 deletions and 59 inversions, of which 88 and 36 were novel.

Compared to humans, we found an enrichment of chimpanzee genes differentially expressed both within deletions and near inversion breakpoints, as well as alterations in genomic interactions from chromatin-conformation maps.

Finally, we focused on 56 genes impacted by structural variants present in chimpanzees but absent in humans and gorillas, which may contribute to chimpanzee-specific traits.

**Attending this webinar, you will:**

- Understand the importance of genetic structural variation in great ape evolution
- Understand how long read and long-range sequencing technologies can be used together to comprehensively identify structural variation
- Describe how expression and chromatin conformation data can be used to explore the functional impact of structural variations

**Speaker Information:**

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**Daniela C. Soto**  
PhD student  
University of California, Davis

 

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