---
title: Identifying Oligonucleotide Impurities and Metabolites With High-Resolution Mass Spectrometry
description: With the rapid increase in the development of oligonucleotide therapeutics and gene therapies, workflows for the identification, characterization and quantification of full-length products, their impurities and metabolites, are critical.
image: https://go.technologynetworks.com/hubfs/36982_TN_WebinarBanner_HighResMassSpec_TD.jpg
---

WEBINAR

# Identifying Oligonucleotide Impurities and Metabolites With High-Resolution Mass Spectrometry

Now available on-demand

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With the rapid increase in the development of oligonucleotide therapeutics and gene therapies, workflows for the identification, characterization and quantification of full-length products, their impurities and metabolites, are critical.

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**Watch On-Demand Today!**

### Webinar Summary

With the rapid increase in the development of oligonucleotide therapeutics and gene therapies, workflows for the identification, characterization and quantification of full-length products, their impurities and metabolites, are critical. High-resolution time-of-flight mass spectrometry (TOF-MS) can be used for this analysis offering several advantages over ligand-binding assays or fluorescence-based liquid chromatography. Notably, TOF-MS can provide simultaneous identification and sequence confirmation for drug substances as well as impurities/metabolites.

In this webinar, a novel LC-MS/MS Q-TOF instrument (ZenoTOF 7600 system, SCIEX) equipped with a patented ion trap will be applied to the acquisition of highly modified oligonucleotides. Furthermore, the advanced data processing capabilities of a novel software application (Molecule Profiler software, SCIEX) will be demonstrated for their ability to enable identification and relative quantification of synthetic impurities as well as metabolites of oligonucleotide therapeutics.

**Attend this webinar to:**

- Explore how accurate mass, isotope patterns and enhancements in MS/MS are employed to find potential impurities/metabolites
- Learn how impurity/metabolite ID can be automated and how structural characterization based on MS/MS spectra can be facilitated
- Discover how oligonucleotide impurity and metabolite analysis using LC-MS/MS can be performed with Molecule Profiler software

**Speaker Information:**

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**Kerstin Pohl**  
Senior Technical Marketing Global Lead for Biopharma LC-MS  
SCIEX

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