Advances in human induced pluripotent stem cell (iPSC) technology allow the generation of donor-derived healthy and diseased cell lines enabling the study of human disease phenotypes that are challenging to reproduce in animal models. Therefore, human iPSCs provide an attractive option for human disease modeling, drug screening, personalized medicine, cell-based therapy, and toxicity studies.
Axol Bioscience has worked with collaborators to develop assays incorporating two, three and four different cell-types. These co-culture models can incorporate donor-matched cell-types or can incorporate one or more disease lines to better investigate the individual and combined contribution of each cell-type in models incorporating actual human cells differentiated into cell-types akin to those found in vivo. This level of refinement, control and human-relevance is often not possible at scale with existing animal, donor and heterologous cell models.
- The development of co-culture disease models
- Co-culture disease models and their relevance in drug screening
