Interrogation and Modulation of the Immunosuppressive Activity of Human TAM-like Macrophages Using In Vitro Cultures

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The tumor microenvironment supports the development of tumor associated macrophages (TAMs) which are characterized by an immune-suppressive phenotype. TAMs can facilitate the proliferation of tumor cells and are able to suppress anti-tumor immune responses within the tumor microenvironment, making them a highly attractive target for the development of innovative cancer immunotherapies.

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  • A suite of assays that can be used to test novel compound activity
  • How to select the most effective therapeutic compounds for further investigation
  • Identification of the most appropriate tumor type for clinical development