In Vitro Approaches To Risk Assess Chemical-Mediated Changes in Thyroid Function

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The hypothalamic-pituitary-thyroid axis (HPT axis) is conserved across vertebrate evolution. Perturbation of thyroid hormone homeostasis (THH) can lead to adverse effects in thyroid function affecting growth, metabolism and cognitive function. In utero, appropriate thyroid hormone concentrations are vital for normal nervous system development and a variety of experimental approaches are required to thoroughly investigate the effects of chemicals on thyroid function.

Download this poster to discover numerous in vitro approaches including:

  • Recombinant deiodinase inhibition
  • In vitro hepatic UGT mRNA expression
  • Thyroid peroxidase inhibition
  • Hepatic T4-glucuronidation analytical method
  • Ex vivo and in vitro T4-glucuronidation
  • Rat sodium iodide symporter inhibition