High-throughput screening (HTS) is a drug discovery strategy used extensively during early-stage pharmaceutical development. The patch clamp technique remains the gold standard for testing the activity of drug compounds on ion channels. Automated patch clamp (APC) is becoming increasingly popular in HTS laboratories, as an alternative method, given its ease-of-use and higher throughput capabilities. APC can be employed at many stages of the drug discovery pipeline – from hit identification and lead optimization through to target validation and safety testing.
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