---
title: Liver-on-Chip and In Silico Modeling for Quantitative Drug Metabolism Studies
description: Understanding the pharmacokinetics (PK) of new drugs has typically relied quite heavily on animal models. However, these models are expensive and often have limited relevance to humans.
image: https://go.technologynetworks.com/hubfs/Technology%20Networks/TN%20Webinars/2021/16th%20September%202021%20-%20CN%20Bio/38623_CNBio_LiverChip_060821_LA.jpg
---

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Webinar

# Liver-on-Chip and *In Silico* Modeling for Quantitative Drug Metabolism Studies

Now Available On-Demand

Understanding the pharmacokinetics (PK) of new drugs has typically relied quite heavily on animal models, however, these models are expensive and often have limited relevance to humans. The development of a Liver-on-a-Chip (LOAC) device, that better recapitulates human physiology compared to standard *in vitro* systems, represents a promising alternative to reduce the use of animal models.

This webinar will examine the benefits of combining LOAC with *in silico* modeling to explore clinical PK predictions of specific reference drugs, including investigations into the intrinsic clearance determinations for high metabolically stable compounds and the quantitation of fractions metabolized by specific enzymes.

**Attend this webinar to learn about:**

- Various applications of Liver-on-a-Chip in quantitative PK
- CYP (Cytochrome P450) and UGT (Uridine Diphosphate-glucuronosyltransferase) metabolism with Liver-on-a-Chip
- Combining *in silico* modeling and experimental data for *in vitro–in vivo* extrapolation
- Liver-on-a-Chip and future perspectives

**Speaker Information:**

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**Dr. Nicolo Milani**

Postdoc Scientist   
Hoffmann-La Roche, Basel Switzerland

 

 

**Attend this webinar to learn about:**

- Various applications of Liver-on-a-Chip in quantitative PK
- CYP (Cytochrome P450) and UGT (Uridine Diphosphate-glucuronosyltransferase) metabolism with Liver-on-a-Chip
- Combining *in silico* modelling and experimental data for *in vitro-in vivo* extrapolation
- Liver-on-a-Chip and future perspectives

Register for FREE Now!

 

 

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