The structural characterization of complex proteins gives researchers a glimpse into their in vivo mechanistic functions and complex chemistries. In the case of drug development, structural information of proteins involved in disease pathways is crucial for downstream rational design of novel therapeutics.
The field of structural biology is currently undergoing a renaissance due to significant advances in cryogenic electron microscopy (cryo-EM) following the emergence of direct electron detectors and advanced computational platforms.
Download this app note to learn more about the recent advances in cryo-EM including:
- Near-atomic resolution of protein structures
- Requiring significantly less protein samples vs crystallography
- Much faster time-to-results and higher sample throughput