In early-stage pharmaceutical research, knowledge of a compound’s metabolism can assist in the identification of structural liabilities that can contribute to non-optimal pharmacokinetics, potentially toxic breakdown products or the potential for drug-drug interactions.
Download this app note to discover how switching from a traditional high flow chromatographic separation to microflow chromatography for metabolite analysis can:
- Improve the sensitivity for the analysis of microsomal incubation samples
- Lead to the identification of more metabolites with a higher degree of confidence
- Provide more complete metabolic profiling from the same amount of sample