DNA methylation is an essential epigenetic modification that influences the control of gene expression. Anomalies in this process can lead to genomic instabilities or issues with transcriptional silencing, which can result in various diseases such as cancer, diabetes, cardiovascular disease, and various inflammatory conditions.
Scientists must therefore access the right tools to effectively study a given sample’s DNA methylation status and better understand genome-wide methylation patterns.Download this listicle to learn more about:
- The limitations of traditional methylation-sequencing workflows
- Improving methyl-seq with enzymatic conversion and target enrichment probe design
- An innovative NGS methylation detection system