Gamma rhythms (30-80 Hz) are modulated during cognition, and impaired gamma rhythms have been associated with Alzheimer's disease (AD).
But do they play a causal role? New evidence shows that non-invasive sensory stimulation using 40 Hz rhythm power and synchrony in AD mouse models reduces AD-like pathology and enhances cognitive function.
Research is ongoing to understand the mechanisms underlying the beneficial effects of 40 Hz stimulation and to translate this intervention for human patients.
Attendees will learn about:
The emergence and role of gamma rhythms in the brain
Evidence of gamma impairment in Alzheimer’s disease (AD) models
Methods for Gamma Entrainment Using Sensory Stimuli (GENUS)
Pathology and symptomatic improvements in AD models resulting from GENUS
Proposed “signatures” of gamma entrainment in the brain, including effects on gene expression and activity of neurons and non-neuronal cell types
Dr. Li-Huei Tsai Director, The Picower Institute for Learning and Memory
Massachusetts Institute of Technology
Technology Networks Limited
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