Understanding Tumor Microenvironment Signaling Pathways and Attempts To Target Components in Solid Cancer Therapy
The tumor microenvironment (TME) is comprised of the tumor, extracellular matrix and various non-transformed cells including fibroblasts, immune infiltrates and vascular vessels. TME plays a key role in tumor initiation, progression, invasion, metastasis and resistance. Understanding TME requires close examination of signaling pathways responsible for its characteristics.
- Receptor tyrosine kinase signaling
- Cytokine receptors
- Ancient signaling