Using LC-MS for Next-Gen Biologics: A Focus on Antibody-Drug Conjugates and Conjugation Chemistry



The use of antibodies as delivery vehicles for drug payloads in antibody–drug conjugates (ADCs) and simplified variants of traditional antibody models (i.e., nanobodies) are particularly versatile biochemical products. The creation of ADCs and nanobodies follows relatively straightforward recombinant production followed by conjugation chemistry routes, but the complexity of such structures requires sensitive and specific analysis by liquid chromatography-mass spectrometry (LC-MS) for quality assessment.

Download this whitepaper to discover how LC-MS:

  • Can deliver unmatched analyte specificity for ADC characterization
  • Allows for high-throughput analyses
  • Is useful in product development